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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
36.36
Human Site:
S728
Identified Species:
57.14
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S728
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S736
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S722
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Dog
Lupus familis
XP_534241
2041
231068
S1146
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S716
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Rat
Rattus norvegicus
P41516
1526
173202
L701
N
D
F
I
N
K
E
L
I
L
F
S
N
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1031
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Chicken
Gallus gallus
O42131
1627
183228
S733
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Frog
Xenopus laevis
NP_001082502
1579
178601
S705
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S727
N
K
E
L
I
L
F
S
N
S
D
N
E
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G622
R
I
L
F
K
Y
D
G
S
V
D
D
E
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
E695
F
S
K
K
K
I
E
E
R
K
D
W
L
S
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K623
Y
S
L
P
E
F
E
K
W
K
D
A
T
D
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
E648
W
E
D
E
Q
D
G
E
A
I
E
L
A
F
S
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K603
T
W
K
Q
K
Y
Y
K
G
L
G
T
S
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
100
100
100
100
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
100
100
N.A.
26.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
7
0
0
7
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
7
7
0
0
0
80
7
0
7
7
% D
% Glu:
0
7
60
7
7
0
20
14
0
0
7
0
67
0
0
% E
% Phe:
7
0
7
7
0
7
60
0
0
0
7
0
0
7
0
% F
% Gly:
0
0
0
0
0
0
7
7
7
0
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
60
7
0
0
7
7
0
0
0
0
7
% I
% Lys:
0
60
14
7
20
7
0
14
0
14
0
0
0
0
7
% K
% Leu:
0
0
14
60
0
60
0
7
0
14
0
7
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
67
0
0
0
7
0
0
0
60
0
0
60
7
0
7
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
7
0
0
0
0
60
0
% R
% Ser:
0
14
0
0
0
0
0
60
7
60
0
7
7
20
67
% S
% Thr:
7
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% V
% Trp:
7
7
0
0
0
0
0
0
7
0
0
7
0
0
0
% W
% Tyr:
7
0
0
0
0
14
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _